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Keep an eye on Closely (one)pentobarbital will lessen the level or result of exemestane by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. For individuals obtaining exemestane which has a powerful CYP3A4 inducer the advisable dose of exemestane is 50 mg day-to-day after a meal.pentobarbital decreases effects of sufentani